Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301687 | 0.80 | LTA4H (0.73) | LTA4HPTGS2MEN1TSHRKMT2A | |
| SCHEMBL31143565 | 0.78 | LTA4H (0.71) | LTA4HPTGS2TSHRDRD3CHRNB2 | |
| SCHEMBL29550011 | 0.77 | LTA4H (0.61) | LTA4HPTGS2HRH1KCNH2CYP2D6 | |
| SCHEMBL29969794 | 0.77 | LTA4H (0.61) | LTA4HPTGS2HRH1KCNH2CYP2D6 | |
| SCHEMBL5802568 | 0.76 | LTA4H (0.55) | LTA4HPTGS2ALDH1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL7399157 | 0.74 | LTA4H (0.54) | LTA4HPTGS2LMNAALDH1A1GMNN | |
| SCHEMBL3363202 | 0.74 | LTA4H (0.54) | LTA4HPTGS2ALDH1A1 | |
| SCHEMBL1680020 | 0.73 | LTA4H (0.51) | LTA4HPTGS2LMNAALDH1A1CYP2D6 | |
| SCHEMBL29104580 | 0.73 | LTA4H (0.63) | LTA4HPTGS2SLC6A4MEN1KMT2A | |
| SCHEMBL4190714 | 0.71 | KDM4E (0.50) | LTA4HPTGS2LMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4551466-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-11-05 | — | — | US | disclosed |