Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | CTSB | P07858 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21437204 | 0.81 | MAPT (0.48) | TDP1ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL9836130 | 0.79 | TDP1 (0.62) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL2431427 | 0.78 | TDP1 (0.50) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL12314708 | 0.78 | TDP1 (0.50) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL4470384 | 0.78 | CTSB (0.55) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL29532198 | 0.78 | TDP1 (0.50) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL27995682 | 0.78 | TDP1 (0.50) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL202880 | 0.75 | POLB (0.51) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL14089776 | 0.74 | CTSB (0.46) | TDP1CTSBALDH1A1NCOA1NCOA3 | |
| SCHEMBL27006369 | 0.74 | PIN1 (0.49) | TDP1CTSBALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-59172472-A | — | — | None | — | — | JP | disclosed |
| CN-101296924-A | Pyrazole-isoquinoline urea derivatives as P38 kinase inhibitors | LILLY CO ELI (US) | 2008-10-29 | — | — | CN | disclosed |
| JP-S59172472-A | ISOQUINOLINE DERIVATIVE AND ITS SALT, THEIR PREPARATION, AND ANTIALLERGIC AGENT CONTAINING SAID COMPOUND AS ACTIVE COMPONENT | FUJISAWA PHARMACEUT CO LTD | 1984-09-29 | — | — | JP | disclosed |