Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.63 |
| ▸ | GABRD | O14764 | 2/20 | 0.63 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.63 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.63 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.63 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.63 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.63 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.63 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.63 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.63 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.63 |
| ▸ | GABRE | P78334 | 2/20 | 0.63 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.63 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.63 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.63 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.63 |
| ▸ | PPARA | Q07869 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30985304 | 0.93 | GABRP (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30985305 | 0.83 | GABRP (0.61) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL31481097 | 0.77 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1969600 | 0.77 | GABRP (0.72) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7386044 | 0.74 | GABRP (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Bicarbonate SCHEMBL10966197 | 0.74 | KCNH2 (0.78) | PPARAKCNH2PPARGKAT8LTB4R | |
| SCHEMBL2754306 | 0.74 | GABRP (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL3719445 | 0.73 | PPARA (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL14354160 | 0.73 | KCNH2 (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL5002869 | 0.73 | GABRP (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064385-B1 | 2,6-DIARYL-PYRIDINECARBOXYLIC ACIDS AND THEIR THERAPEUTIC UTILITY | THE UPJOHN COMPANY (US) | 1986-04-02 | — | — | EP | disclosed |
| US-4377586-A | Diuretic 2,6-diaryl-4-pyridine carboxylic acids | THE UPJOHN COMPANY (US) | 1983-03-22 | — | — | US | disclosed |
| EP-0064385-A1 | 2,6-Diaryl-pyridinecarboxylic acids and their therapeutic utility | THE UPJOHN COMPANY (US) | 1982-11-10 | — | — | EP | disclosed |
| EP-0064385-A1 | 2,6-Diaryl-pyridinecarboxylic acids and their therapeutic utility | THE UPJOHN COMPANY (US) | 1982-11-10 | — | — | EP | disclosed |