Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25987654 | 0.89 | POLB (0.60) | POLBMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3186208 | 0.87 | CYP3A4 (0.58) | MEN1KMT2AALDH1A1KDM4EHDAC3 | |
| SCHEMBL6486455 | 0.83 | ALDH1A1 (0.58) | POLBMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8692757 | 0.82 | CYP3A4 (0.53) | MEN1KMT2AALDH1A1KDM4EHDAC3 | |
| SCHEMBL6136514 | 0.81 | NPC1 (0.53) | POLBMEN1KMT2AALDH1A1USP2 | |
| SCHEMBL28495982 | 0.81 | HTT (0.60) | MEN1KMT2AALDH1A1CYP3A4USP2 | |
| SCHEMBL30496700 | 0.80 | POLB (0.66) | POLBMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL10956809 | 0.79 | NPC1 (0.55) | POLBMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL7986608 | 0.79 | CYP3A4 (0.61) | MEN1KMT2AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL23389370 | 0.79 | POLB (0.58) | POLBMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446141-A | Hypotensive piperidine derivatives | KYOWA HAKKO KOGYO CO. (JP) | 1984-05-01 | — | — | US | disclosed |
| EP-0018417-A1 | Novel piperidine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1980-11-12 | — | — | EP | disclosed |