Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SHBG | P04278 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11036779 | 1.00 | STS (0.44) | STSESR1CHRM2ACHESLC6A2 | |
| SCHEMBL11336320 | 1.00 | STS (0.44) | STSESR1CHRM2ACHESLC6A2 | |
| SCHEMBL9215597 | 0.87 | SHBG (0.39) | ESR1CYP2C19SHBGMAPK1POLB | |
| SCHEMBL9215604 | 0.87 | SHBG (0.39) | ESR1CYP2C19SHBGMAPK1POLB | |
| SCHEMBL13855720 | 0.85 | SHBG (0.55) | STSESR1CYP2C19SHBGMAPK1 | |
| SCHEMBL4115261 | 0.85 | SHBG (0.55) | STSESR1CYP2C19SHBGMAPK1 | |
| SCHEMBL28827028 | 0.85 | SHBG (0.55) | STSESR1CYP2C19SHBGMAPK1 | |
| SCHEMBL28060038 | 0.85 | SHBG (0.55) | STSESR1CYP2C19SHBGMAPK1 | |
| SCHEMBL4115264 | 0.85 | SHBG (0.55) | STSESR1CYP2C19SHBGMAPK1 | |
| SCHEMBL11332715 | 0.83 | SHBG (0.59) | ESR1SLC6A4CYP2C19SHBGMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4552871-A | ALDOSTERONE-ANTAGONISTIC, DIURETICS | CIBA GEIGY CORPORATION (US) | 1985-11-12 | — | — | US | claimed |
| EP-0122882-A1 | Steroids of the 20-spiroxan series, process for their preparation, pharmaceutical compositions containing them and use of these compositions | CIBA-GEIGY AG (CH) | 1984-10-24 | — | — | EP | claimed |
| US-4552871-A | ALDOSTERONE-ANTAGONISTIC, DIURETICS | CIBA GEIGY CORPORATION (US) | 1985-11-12 | — | — | US | disclosed |
| EP-0122882-A1 | Steroids of the 20-spiroxan series, process for their preparation, pharmaceutical compositions containing them and use of these compositions | CIBA-GEIGY AG (CH) | 1984-10-24 | — | — | EP | disclosed |
| US-4267106-A | New process for the preparation 17β-hydroxy-3-oxo-17α-pregnene and pregnadiene-21-carboxylic acid γ-lactones | GIST BROCADES N.V. (NL) | 1981-05-12 | — | — | US | disclosed |