Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | PLD2 | O14939 | 1/20 | 0.42 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11037133 | 0.89 | CHRM1 (0.66) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11038789 | 0.84 | OPRM1 (0.61) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11053770 | 0.83 | OPRM1 (0.61) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11036225 | 0.82 | CHRM1 (0.42) | CHRM1OPRM1SMN1; SMN2HTR1ADRD2 | |
| SCHEMBL11038937 | 0.81 | OPRM1 (0.58) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11159626 | 0.79 | OPRM1 (0.68) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11037976 | 0.79 | OPRM1 (0.58) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11038979 | 0.79 | OPRM1 (0.62) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11036223 | 0.78 | OPRM1 (0.61) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11039285 | 0.78 | OPRM1 (0.63) | CHRM1OPRM1DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040639-B1 | ISOXAZOLE DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1984-05-30 | — | — | EP | disclosed |
| US-4397853-A | PSYCHOTROPIC, ANTIEMETIC | YOSHITOMI PHARMACEUTICAL INDUSTRIES LTD. (JP) | 1983-08-09 | — | — | US | disclosed |
| EP-0040639-A1 | ISOXAZOLE DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1981-12-02 | — | — | EP | disclosed |