Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.65 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 3/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11038789 | 0.95 | OPRM1 (0.61) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11053770 | 0.94 | OPRM1 (0.61) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11038937 | 0.91 | OPRM1 (0.58) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11159626 | 0.90 | OPRM1 (0.68) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11038979 | 0.89 | OPRM1 (0.62) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11037100 | 0.89 | CHRM1 (0.52) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11037976 | 0.89 | OPRM1 (0.58) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11039285 | 0.89 | OPRM1 (0.63) | CHRM1OPRM1DRD2DRD3CYP2D6 | |
| SCHEMBL11036223 | 0.88 | OPRM1 (0.61) | CHRM1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL11323530 | 0.87 | OPRM1 (0.61) | CHRM1OPRM1HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040639-B1 | ISOXAZOLE DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1984-05-30 | — | — | EP | disclosed |
| US-4397853-A | PSYCHOTROPIC, ANTIEMETIC | YOSHITOMI PHARMACEUTICAL INDUSTRIES LTD. (JP) | 1983-08-09 | — | — | US | disclosed |
| EP-0040639-A1 | ISOXAZOLE DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1981-12-02 | — | — | EP | disclosed |