Acetoacetic Acid

Acetoacetic Acid

SCHEMBL11037151

CC(=O)CC(=O)O.Nc1ccc(S(=O)(=O)O)cc1

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.62
ALDH1A1 P00352 3/20 0.62
NT5E P21589 1/20 0.62
SMN1; SMN2 Q16637 2/20 0.50
DHFR P00374 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
PKM P14618 1/20 0.46
CYP2C19 P33261 1/20 0.46
CA1 P00915 4/20 0.45
CA2 P00918 4/20 0.45
CA12 O43570 2/20 0.45
CA9 Q16790 2/20 0.45
GAA P10253 1/20 0.43
MMP1 P03956 1/20 0.43
MMP2 P08253 1/20 0.43
MMP9 P14780 1/20 0.43
MMP8 P22894 1/20 0.43
MMP13 P45452 1/20 0.43
SLC1A3 P43003 1/20 0.43
SLC1A2 P43004 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL2282444 0.85 TSHR (0.78) TSHRALDH1A1NT5ESMN1; SMN2DHFR
Acetic Acid SCHEMBL27344101 0.85 TSHR (0.78) TSHRALDH1A1NT5ESMN1; SMN2DHFR
Acetoacetic Acid SCHEMBL10586878 0.85 MAPT (0.48) TSHRSMN1; SMN2DHFRTDP1PKM
Acetoacetic Acid SCHEMBL8378766 0.84 KEAP1 (0.49) TSHRALDH1A1SMN1; SMN2TDP1PKM
Acetone SCHEMBL27689791 0.83 TSHR (0.82) TSHRALDH1A1NT5ESMN1; SMN2DHFR
Bicarbonate SCHEMBL11488986 0.81 TSHR (0.86) TSHRALDH1A1NT5ESMN1; SMN2DHFR
Acetoacetic Acid SCHEMBL11244946 0.81 ALDH1A1 (0.67) TSHRALDH1A1TDP1CA1CA2
Acetic Acid SCHEMBL28774212 0.80 TSHR (0.75) TSHRALDH1A1NT5ESMN1; SMN2DHFR
SCHEMBL30532022 0.80 TSHR (0.75) TSHRALDH1A1NT5ESMN1; SMN2DHFR
Oxalic Acid SCHEMBL27261783 0.79 TSHR (0.82) TSHRALDH1A1NT5ESMN1; SMN2DHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4540776-A Reactive fluorotriazinylaminonaphthotriazolyphenylazopyridone or pyrimidone dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1985-09-10 US disclosed
US-4354968-A Azo reactive dyestuffs having an aryl-triazinyl-aryl diazo component BAYER AKTIENGESELLSCHAFT (DE) 1982-10-19 US disclosed
US-4348204-A COTTON, REGENERATED CELLULOSE, PAPER; TETRAKISAZO DYES CASSELLA AKTIENGESELLSCHAFT (DE) 1982-09-07 US disclosed
US-4225492-A Water-soluble disazo dyestuffs, prepared from unsymmetrical heterocyclic diamines CASSELLA AKTIENGESELLSCHAFT (DE) 1980-09-30 US disclosed
US-4144231-A Soluble trisazo dyestuffs containing a 2-phenyl-benzimidazolyl, -benzoxazolyl or -benzthiazolyl middle component CASSELLA AKTIENGESELLSCHAFT (DE) 1979-03-13 US disclosed
US-4143033-A WATER-SOLUBLE DISAZO DYESTUFFS CONTAINING A 2-PHENYL-BENZIMIDAZOLYL,-BENZOXAZOLYL OR-BENZTHIAZOLYL MIDDLE COMPONENT CASSELLA AKTIENGESELLSCHAFT (DE) 1979-03-06 US disclosed
US-4137228-A HIGH TINCTORIAL STRENGTH, COLORFASTNESS CASSELLA AKTIENGESELLSCHAFT (DE) 1979-01-30 US disclosed
US-3966703-A Asymmetrical frisazo dyestuffs derived from diazotized 2,7-diamino-carbazole BAYER AKTIENGESELLSCHAFT (DT) 1976-06-29 US disclosed