Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 7/20 | 0.41 |
| ▸ | HTR1A | P08908 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11037586 | 0.99 | HTR7 (0.41) | HTR7HTR1AKCNH2HRH3ACHE | |
| Hydrochloric Acid SCHEMBL11034929 | 0.90 | HTR7 (0.41) | HTR7HTR1AKCNH2HRH3ACHE | |
| SCHEMBL11036104 | 0.88 | KDM4E (0.41) | HTR7HTR1ADRD3DRD2POLB | |
| SCHEMBL11287903 | 0.88 | HRH1 (0.42) | HTR7HTR1AKCNH2DRD3DRD2 | |
| Hydrochloric Acid SCHEMBL11036483 | 0.87 | HRH1 (0.43) | HTR7HTR1AKCNH2DRD3DRD2 | |
| SCHEMBL11034686 | 0.86 | KDM4E (0.41) | HTR7HTR1AKCNH2DRD3DRD2 | |
| SCHEMBL11125568 | 0.82 | HTR7 (0.54) | HTR7HTR1AHRH3ACHEF2 | |
| SCHEMBL11100917 | 0.82 | SCN9A (0.37) | KCNH2DRD3 | |
| Hydrochloric Acid SCHEMBL11034454 | 0.81 | HRH1 (0.38) | KCNH2DRD3 | |
| Hydrochloric Acid SCHEMBL10931643 | 0.81 | HTR7 (0.53) | HTR7HTR1AHRH3ACHEF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0048705-B1 | 2-(4-(DIPHENYLMETHYLENE)-1-PIPERIDINYL)-ACETIC ACIDS AND THEIR AMIDES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | U C B, S.A. (BE) | 1984-07-11 | — | — | EP | claimed |
| EP-0048705-A1 | 2-(4-(Diphenylmethylene)-1-piperidinyl)-acetic acids and their amides, their preparation and pharmaceutical preparations containing them | U C B, S.A. (BE) | 1982-03-31 | — | — | EP | claimed |
| EP-0048705-B1 | 2-(4-(DIPHENYLMETHYLENE)-1-PIPERIDINYL)-ACETIC ACIDS AND THEIR AMIDES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | U C B, S.A. (BE) | 1984-07-11 | — | — | EP | disclosed |
| US-4443460-A | ANTIALLERGENS, ANTIHISTAMINES, ANTISPASMODICS, BRONCHODILATORS | UCB, SOCIETE ANONYME (BE) | 1984-04-17 | — | — | US | disclosed |
| EP-0048705-A1 | 2-(4-(Diphenylmethylene)-1-piperidinyl)-acetic acids and their amides, their preparation and pharmaceutical preparations containing them | U C B, S.A. (BE) | 1982-03-31 | — | — | EP | disclosed |