Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL224693 | 0.84 | PLAU (0.57) | PLAUALDH1A1HSD17B10CYP3A4CASP1 | |
| SCHEMBL25410815 | 0.80 | NQO2 (0.38) | ALDH1A1HSD17B10KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL27659879 | 0.78 | PLAU (0.59) | PLAUALDH1A1HSD17B10CYP3A4CASP1 | |
| SCHEMBL31323067 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HSD17B10CYP3A4HIF1ATDP1 | |
| SCHEMBL31038169 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HSD17B10CYP3A4HIF1ATDP1 | |
| SCHEMBL385875 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HSD17B10CYP3A4HIF1ATDP1 | |
| SCHEMBL11258825 | 0.74 | IFNAR1 (0.35) | ALDH1A1MAPTSMN1; SMN2LMNATSHR | |
| SCHEMBL8035199 | 0.74 | CYP1A2 (0.52) | ALDH1A1MAPTPOLBCYP1A2CYP2A6 | |
| SCHEMBL3698024 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HSD17B10HIF1ATDP1KDM4E | |
| SCHEMBL14100536 | 0.74 | CYP1A2 (0.63) | PLAUALDH1A1HSD17B10CYP3A4CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0052932-B1 | 2-AMINOTETRALIN COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS HAVING CENTRAL ALPHA1 AGONIST ACTIVITY | SMITHKLINE BECKMAN CORPORATION (US) | 1984-02-22 | — | — | EP | disclosed |
| EP-0052932-A1 | 2-Aminotetralin compounds and pharmaceutical compositions having central alpha1 agonist activity | SMITHKLINE BECKMAN CORPORATION (US) | 1982-06-02 | — | — | EP | disclosed |
| US-4320148-A | ANTIDEPRESSANTS | SMITHKLINE CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |