Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1402214 | 0.78 | CYP1A2 (0.55) | CYP1A2CYP2A6MTNR1AMTNR1BSIRT2 | |
| SCHEMBL25410815 | 0.77 | NQO2 (0.38) | CYP1A2MTNR1AMTNR1BKMT2AMEN1 | |
| SCHEMBL28949660 | 0.77 | MTNR1A (0.46) | CYP1A2CYP2A6MTNR1AMTNR1B | |
| SCHEMBL5510892 | 0.76 | CYP1A2 (0.59) | CYP1A2CYP2A6MTNR1AMTNR1BSIRT2 | |
| SCHEMBL29869216 | 0.76 | CYP1A2 (0.57) | CYP1A2CYP2A6MTNR1AMTNR1BCYP1A1 | |
| SCHEMBL443271 | 0.76 | CYP1A2 (0.57) | CYP1A2CYP2A6MTNR1AMTNR1BCYP1A1 | |
| SCHEMBL3698024 | 0.75 | ALDH1A1 (0.41) | CYP1A2CYP2A6CYP1B1KMT2AMEN1 | |
| SCHEMBL1806698 | 0.74 | CYP1A2 (0.55) | CYP1A2CYP2A6MTNR1AMTNR1BSIRT2 | |
| SCHEMBL7514393 | 0.74 | CYP1A2 (0.55) | CYP1A2CYP2A6MTNR1AMTNR1BSIRT2 | |
| SCHEMBL11039342 | 0.74 | PLAU (0.53) | CYP1A2CYP2A6KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150397-A | 5-(PYRIDYL, FURYL, OR THIENYL SUBSTITUTED)-6-SUBSTITUTED-2--2-NAPHTHALENESULFONAMIDES OF GIVEN FORMULA; INHIBITORS OF PROSTAGLANDIN G/H SYNTHASE; TREATING INFLAMMATORY DISEASE SUCH AS GOUT, ARTHRITIS, MYOSITIS, SYNOVITIS | SYNTEX (U.S.A.) INC. (US) | 2000-11-21 | — | — | US | disclosed |