Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.54 |
| ▸ | DRD3 | P35462 | 5/20 | 0.54 |
| ▸ | DRD4 | P21917 | 3/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11037239 | 0.95 | DRD2 (0.54) | DRD2DRD3DRD4ADRA1AHTR1D | |
| SCHEMBL11038660 | 0.85 | DRD2 (0.59) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| SCHEMBL11039977 | 0.85 | DRD2 (0.59) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| SCHEMBL7544212 | 0.83 | DRD2 (0.69) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| SCHEMBL7548060 | 0.83 | DRD2 (0.69) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| Hydrochloric Acid SCHEMBL7541435 | 0.82 | DRD2 (0.68) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| Hydrochloric Acid SCHEMBL7547547 | 0.82 | DRD2 (0.68) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| SCHEMBL11035639 | 0.81 | MTNR1A (0.57) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL11040989 | 0.80 | DRD2 (0.59) | DRD2DRD3DRD4ADRA1AMTNR1A | |
| SCHEMBL11053196 | 0.80 | DRD2 (0.59) | DRD2DRD3DRD4ADRA1AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0052932-B1 | 2-AMINOTETRALIN COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS HAVING CENTRAL ALPHA1 AGONIST ACTIVITY | SMITHKLINE BECKMAN CORPORATION (US) | 1984-02-22 | — | — | EP | disclosed |
| EP-0052932-A1 | 2-Aminotetralin compounds and pharmaceutical compositions having central alpha1 agonist activity | SMITHKLINE BECKMAN CORPORATION (US) | 1982-06-02 | — | — | EP | disclosed |
| US-4320148-A | ANTIDEPRESSANTS | SMITHKLINE CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |