Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11043360 | 0.95 | MAPK1 (0.52) | MAPK1CLK1HRH3ALOX5ADORA1 | |
| SCHEMBL11038375 | 0.87 | HRH3 (0.58) | MAPK1HRH3HTR7ALDH1A1NPC1 | |
| SCHEMBL11041661 | 0.85 | HRH3 (0.45) | CLK1HRH3ALOX5ADORA1HTR7 | |
| SCHEMBL11038402 | 0.81 | ALOX5 (0.44) | HRH3ALOX5ADORA1CYP2A6ALDH1A1 | |
| SCHEMBL7649606 | 0.80 | HRH3 (0.45) | CLK1HRH3ALOX5ADORA1HTR7 | |
| SCHEMBL11040663 | 0.80 | MEN1 (0.47) | HRH3ALOX5ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL11040063 | 0.80 | ALOX5 (0.45) | MAPK1CLK1HRH3ALOX5CYP2A6 | |
| SCHEMBL11753751 | 0.78 | HRH3 (0.61) | MAPK1HRH3HTR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL11040676 | 0.77 | ALOX5 (0.50) | HRH3ALOX5ADORA1CYP2A6ALDH1A1 | |
| SCHEMBL11039020 | 0.77 | HRH3 (0.45) | MAPK1HRH3ADORA1HTR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | claimed |
| EP-0061425-A2 | Thiazole derivatives, processes for their preparation, medicaments containing them and their use | CIBA-GEIGY AG (CH) | 1982-09-29 | — | — | EP | claimed |
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |
| EP-0061425-A2 | Thiazole derivatives, processes for their preparation, medicaments containing them and their use | CIBA-GEIGY AG (CH) | 1982-09-29 | — | — | EP | disclosed |