Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11043360 | 0.85 | MAPK1 (0.52) | MEN1KMT2APKMALOX5HRH3 | |
| SCHEMBL7649606 | 0.83 | HRH3 (0.45) | KMT2AALOX5HRH3ALDH1A1KDM4E | |
| SCHEMBL11040063 | 0.82 | ALOX5 (0.45) | MEN1KMT2APKMAPEX1ALOX5 | |
| SCHEMBL11040676 | 0.81 | ALOX5 (0.50) | MEN1KMT2AALOX5HRH3ALDH1A1 | |
| SCHEMBL11042391 | 0.80 | PTGS2 (0.54) | MEN1KMT2APOLBAPEX1RECQL | |
| SCHEMBL11040740 | 0.80 | MAPK1 (0.52) | MEN1KMT2APKMPOLBALOX5 | |
| SCHEMBL7621307 | 0.79 | ALOX5 (0.48) | ALOX5HRH3ALDH1A1KDM4EMAPT | |
| SCHEMBL11041661 | 0.78 | HRH3 (0.45) | KMT2AALOX5HRH3ALDH1A1KDM4E | |
| SCHEMBL11750819 | 0.78 | GAA (0.52) | MEN1KMT2APKMPOLBAPEX1 | |
| SCHEMBL11753338 | 0.74 | PTGS2 (0.48) | MEN1KMT2APKMPOLBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |
| EP-0061425-A2 | Thiazole derivatives, processes for their preparation, medicaments containing them and their use | CIBA-GEIGY AG (CH) | 1982-09-29 | — | — | EP | disclosed |