Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9841168 | 0.80 | MMP9 (0.44) | KMT2AMEN1MMP9MMP8MMP2 | |
| SCHEMBL11042580 | 0.77 | POLB (0.44) | KMT2APOLBCASP6MEN1MMP9 | |
| SCHEMBL11041928 | 0.77 | KMT2A (0.71) | KMT2APOLBMEN1MMP9MMP8 | |
| SCHEMBL15608259 | 0.75 | KMT2A (0.43) | KMT2ABRD4POLBCASP6MEN1 | |
| SCHEMBL9802533 | 0.74 | MMP9 (0.54) | KMT2APOLBMEN1MMP9MMP8 | |
| SCHEMBL2499492 | 0.73 | BRD4 (0.57) | KMT2ABRD4POLBCASP6MEN1 | |
| SCHEMBL2502271 | 0.73 | BRD4 (0.57) | KMT2ABRD4POLBCASP6MEN1 | |
| SCHEMBL2497474 | 0.73 | BRD4 (0.57) | KMT2ABRD4POLBCASP6MEN1 | |
| SCHEMBL11042940 | 0.73 | KMT2A (0.50) | KMT2AMEN1MMP9MMP8PDK2 | |
| SCHEMBL11042592 | 0.71 | MMP9 (0.57) | KMT2AMEN1MMP9MMP8MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4454320-A | Process for 5-substituted dialuric acids | PFIZER INC. (US) | 1984-06-12 | — | — | US | disclosed |
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |