Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 5/20 | 0.55 |
| ▸ | TLR2 | O60603 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCND1 | P24385 | 2/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.40 |
| ▸ | FURIN | P09958 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11041123 | 1.00 | TLR4 (0.55) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11045237 | 0.90 | TLR4 (0.58) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11045240 | 0.90 | TLR4 (0.58) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11045209 | 0.88 | KDM4E (0.61) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11045213 | 0.88 | KDM4E (0.61) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL17926721 | 0.82 | TLR4 (0.46) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4414011 | 0.81 | KDM4E (0.47) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4414013 | 0.81 | KDM4E (0.47) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7341112 | 0.81 | PTGS1 (0.53) | KMT2AMAOAMAOB | |
| SCHEMBL7541618 | 0.81 | LCK (0.58) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |