Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TLR4 | O00206 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11045213 | 1.00 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2TLR4TLR2 | |
| SCHEMBL11041123 | 0.88 | TLR4 (0.55) | KDM4EALDH1A1SMN1; SMN2TLR4TLR2 | |
| SCHEMBL11041121 | 0.88 | TLR4 (0.55) | KDM4EALDH1A1SMN1; SMN2TLR4TLR2 | |
| SCHEMBL4414011 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2TLR4TLR2 | |
| SCHEMBL4414013 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2TLR4TLR2 | |
| SCHEMBL21457214 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2TLR4TLR2 | |
| SCHEMBL21457217 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2TLR4TLR2 | |
| SCHEMBL11045237 | 0.84 | TLR4 (0.58) | KDM4EALDH1A1SMN1; SMN2TLR4TLR2 | |
| SCHEMBL11045240 | 0.84 | TLR4 (0.58) | KDM4EALDH1A1SMN1; SMN2TLR4TLR2 | |
| SCHEMBL7342257 | 0.83 | ESR1 (0.49) | KDM4EALDH1A1SMN1; SMN2RELACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |