Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 2/20 | 0.58 |
| ▸ | TLR2 | O60603 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.46 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11045237 | 1.00 | TLR4 (0.58) | TLR4TLR2TSHRCYSLTR2SMPD1 | |
| SCHEMBL11041123 | 0.90 | TLR4 (0.55) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11041121 | 0.90 | TLR4 (0.55) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL17926721 | 0.87 | TLR4 (0.46) | TLR4TLR2CYSLTR2KDM4EALDH1A1 | |
| SCHEMBL11045213 | 0.84 | KDM4E (0.61) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11045209 | 0.84 | KDM4E (0.61) | TLR4TLR2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7539459 | 0.82 | TLR4 (0.59) | TLR4TLR2TSHRCYSLTR2SMPD1 | |
| SCHEMBL11308399 | 0.82 | NR5A1 (0.51) | TSHRPLA2G4B | |
| SCHEMBL11320638 | 0.82 | NR5A1 (0.51) | TSHRPLA2G4B | |
| SCHEMBL7278713 | 0.82 | NR5A1 (0.51) | TSHRPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |