Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007112 | 0.78 | ALDH1A1 (0.42) | KDM4EALDH1A1POLBEGLN2LRRK2 | |
| SCHEMBL30692909 | 0.78 | ALDH1A1 (0.42) | KDM4EALDH1A1POLBEGLN2LRRK2 | |
| SCHEMBL12498325 | 0.78 | EGLN2 (0.36) | KDM4EALDH1A1POLBEGLN2IDO1 | |
| SCHEMBL1972185 | 0.75 | EGLN2 (0.34) | KDM4EALDH1A1EGLN2IDO1TDO2 | |
| SCHEMBL23500465 | 0.75 | ALDH1A1 (0.36) | KDM4EALDH1A1POLBLRRK2KMO | |
| SCHEMBL20899365 | 0.75 | KDM4E (0.36) | KDM4EALDH1A1POLBLRRK2KMO | |
| SCHEMBL29672973 | 0.75 | KDM4E (0.40) | KDM4EALDH1A1POLBEGLN2IDO1 | |
| SCHEMBL3360364 | 0.75 | KDM4E (0.36) | KDM4EALDH1A1POLBLRRK2KMO | |
| SCHEMBL26331236 | 0.75 | CSNK1A1 (0.37) | KDM4EALDH1A1POLBIDO1TDO2 | |
| SCHEMBL3095407 | 0.75 | KDM4E (0.40) | KDM4EALDH1A1POLBEGLN2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668163-B1 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED 4-AMINO-3-CHLORO-5-FLUORO-PICOLINATES | DOW AGROSCIENCES LLC (US) | 2017-05-10 | — | — | EP | disclosed |
| US-9598368-B2 | Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted)picolinates | DOW AGROSCIENCES LLC (US) | 2017-03-21 | — | — | US | disclosed |
| EP-2901857-B1 | Process for the preparation of 3-chloro-4,5,6-trifluoro-picolinonitrile | DOW AGROSCIENCES LLC (US) | 2017-03-01 | — | — | EP | disclosed |
| US-9452984-B2 | Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted) picolinates | DOW AGROSCIENCES LLC (US) | 2016-09-27 | — | — | US | disclosed |
| EP-2667713-B1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED)PICOLINATES | DOW AGROSCIENCES LLC (US) | 2016-05-04 | — | — | EP | disclosed |
| US-20150274669-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES | DOW AGROSCIENCES LLC (US) | 2015-10-01 | — | — | US | disclosed |
| EP-2901857-A1 | Process for the preparation of 3-chloro-4,5,6-trifluoro-picolinonitrile | Dow AgroSciences LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| US-9067890-B2 | Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted) picolinates | DOW AGROSCIENCES LLC (US) | 2015-06-30 | — | — | US | disclosed |
| US-20140142317-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES | DOW AGROSCIENCES LLC (US) | 2014-05-22 | — | — | US | disclosed |
| US-20140046070-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED)PICOLINATES | DOW AGROSCIENCES LLC (US) | 2014-02-13 | — | — | US | disclosed |
| US-8609853-B2 | Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted) picolinates | DOW AGROSCIENCES, LLC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-20120190857-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES | DOW AGROSCIENCES LLC (US) | 2012-07-26 | — | — | US | disclosed |
| US-20120190858-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES | DOW AGROSCIENCES LLC (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190858-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES | CYP4F3, CYP4F12, CYP4F8 | KDM4E 684/4885ALDH1A1 1387/4885POLB 2458/4885 |
| US-20150274669-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES | CYP4F3, AFF4, CYP4F12 | KDM4E 732/4885ALDH1A1 2604/4885POLB 2632/4885 |
| US-20140046070-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED)PICOLINATES | CYP4F3, CYP4F12, CYP4F8 | KDM4E 684/4885ALDH1A1 1387/4885POLB 2458/4885 |
| US-20140142317-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES | CYP4F3, AFF4, CYP4F12 | KDM4E 732/4885ALDH1A1 2604/4885POLB 2632/4885 |
| US-20120190857-A1 | PROCESS FOR THE PREPARATION OF 4-AMINO-3-CHLORO-5-FLUORO-6-(SUBSTITUTED) PICOLINATES | CYP4F3, AFF4, CYP4F12 | KDM4E 732/4885ALDH1A1 2604/4885POLB 2632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.