Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.64 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11496541 | 0.90 | MTNR1A (0.72) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL11041081 | 0.82 | MTNR1A (0.62) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL7661182 | 0.80 | MTNR1A (0.59) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL3919777 | 0.78 | MTNR1A (1.00) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL11035639 | 0.78 | MTNR1A (0.57) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL11260202 | 0.77 | MTNR1A (0.59) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL7021164 | 0.77 | MTNR1A (1.00) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL9731034 | 0.77 | MTNR1A (1.00) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL11960204 | 0.77 | MTNR1A (1.00) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL8410102 | 0.75 | MTNR1A (0.59) | MTNR1AMTNR1BCA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0052932-B1 | 2-AMINOTETRALIN COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS HAVING CENTRAL ALPHA1 AGONIST ACTIVITY | SMITHKLINE BECKMAN CORPORATION (US) | 1984-02-22 | — | — | EP | disclosed |
| EP-0052932-A1 | 2-Aminotetralin compounds and pharmaceutical compositions having central alpha1 agonist activity | SMITHKLINE BECKMAN CORPORATION (US) | 1982-06-02 | — | — | EP | disclosed |
| US-4320148-A | ANTIDEPRESSANTS | SMITHKLINE CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |