Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D known ✓ | P28221 | 3/20 | 0.50 |
| ▸ | HTR1B known ✓ | P28222 | 2/20 | 0.50 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 11/20 | 0.66 |
| ▸ | DRD3 | P35462 | 10/20 | 0.66 |
| ▸ | DRD4 | P21917 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7336396 | 0.86 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL7336392 | 0.86 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7424159 | 0.85 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7424155 | 0.85 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL17318066 | 0.81 | DRD2 (0.97) | DRD2DRD3DRD4HTR1DHTR1A | |
| Bromide SCHEMBL9117539 | 0.81 | DRD2 (0.97) | DRD2DRD3DRD4HTR1DHTR1A | |
| Bromide SCHEMBL29588360 | 0.81 | DRD2 (0.97) | DRD2DRD3DRD4HTR1DHTR1A | |
| SCHEMBL11042664 | 0.81 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL1682786 | 0.80 | DRD2 (1.00) | DRD2DRD3DRD4HTR1DHTR1A | |
| SCHEMBL1682783 | 0.80 | DRD2 (1.00) | DRD2DRD3DRD4HTR1DHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4442126-A | PARKINSON*S DISEASE, CARDIOVASCULAR DISORDERS | SYNTHELABO (FR) | 1984-04-10 | — | — | US | disclosed |