Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.53 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.53 |
| ▸ | HTR1D known ✓ | P28221 | 2/20 | 0.52 |
| ▸ | HTR1B known ✓ | P28222 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 11/20 | 0.69 |
| ▸ | DRD3 | P35462 | 8/20 | 0.69 |
| ▸ | DRD4 | P21917 | 3/20 | 0.69 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7336392 | 1.00 | DRD2 (0.69) | DRD2DRD3DRD4DRD1ADRA1D | |
| SCHEMBL7424155 | 0.99 | DRD2 (0.71) | DRD2DRD3DRD4DRD1ADRA1D | |
| SCHEMBL7424159 | 0.99 | DRD2 (0.71) | DRD2DRD3DRD4DRD1ADRA1D | |
| Bromide SCHEMBL8979317 | 0.92 | DRD2 (0.60) | DRD2DRD3DRD4DRD1ADRA1D | |
| Bromide SCHEMBL7401668 | 0.92 | DRD2 (0.60) | DRD2DRD3DRD4DRD1ADRA1D | |
| SCHEMBL9295674 | 0.90 | DRD2 (0.61) | DRD2DRD3DRD4DRD1ADRA1D | |
| Bromide SCHEMBL7271594 | 0.87 | ADRA1D (0.63) | DRD2DRD3DRD4DRD1ADRA1D | |
| Bromide SCHEMBL11042776 | 0.86 | DRD2 (0.66) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7279815 | 0.86 | ADRA1D (0.64) | DRD2DRD3DRD4DRD1ADRA1D | |
| Bromide SCHEMBL9117539 | 0.83 | DRD2 (0.97) | DRD2DRD3DRD4DRD1HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781126-B1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON SPA (IT) | 2001-12-12 | — | — | EP | disclosed |
| US-6080768-A | USEFUL IN THE TREATMENT OF ARTERIAL HYPERTENSION AND HEART FAILURE, RENAL INSUFFICIENCY, PERIPHERAL ARTERIOPATHIES AND CEREBROVASCULAR INSUFFICIENCIES | ZAMBON GROUP S.P.A. (IT) | 2000-06-27 | — | — | US | disclosed |
| EP-0781268-B1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON SPA (IT) | 1999-04-07 | — | — | EP | disclosed |
| US-5747513-A | HYPOTENSIVE AGENTS, HEART FAILURE AND CEREBROVASCULAR INSUFFICIENCY | ZAMBON GROUP, S.P.A. (IT) | 1998-05-05 | — | — | US | disclosed |
| EP-0719252-B1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON SPA (IT) | 1998-02-18 | — | — | EP | disclosed |
| US-5674909-A | FOR TREATMENT OF CARDIOVASCULAR DISORDERS | ZAMBON GROUP (IT) | 1997-10-07 | — | — | US | disclosed |
| EP-0781126-A2 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1997-07-02 | — | — | EP | disclosed |
| EP-0781268-A1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1997-07-02 | — | — | EP | disclosed |
| EP-0719252-A1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1996-07-03 | — | — | EP | disclosed |
| EP-0585440-B1 | 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES ACTIVE ON THE CARDIOVASCULAR SYSTEM, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON SPA (IT) | 1996-05-08 | — | — | EP | disclosed |
| WO-1996008463-A1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.P.A. (IT) | 1996-03-21 | — | — | WO | disclosed |
| WO-1996008228-A2 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRO-NAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.P.A. (IT) | 1996-03-21 | — | — | WO | disclosed |
| US-5451608-A | 2-amino-1,2,3,4-tetrahydronaphthalene derivatives active on the cardiovasular system, processes for their preparation and pharmaceutical compositions containing them | ZAMBON GROUP S.P.A. (IT) | 1995-09-19 | — | — | US | disclosed |
| US-5407956-A | Hypotensive agents, kidney disorders | ZAMBON GROUP S.P.A. (IT) | 1995-04-18 | — | — | US | disclosed |
| WO-1995007885-A1 | DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.P.A. (IT) | 1995-03-23 | — | — | WO | disclosed |
| EP-0585440-A1 | 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES ACTIVE ON THE CARDIOVASCULAR SYSTEM, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | ZAMBON SPA (IT) | 1994-03-09 | — | — | EP | disclosed |
| WO-1993019036-A1 | 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES ACTIVE ON THE CARDIOVASCULAR SYSTEM, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON GROUP S.P.A. (IT) | 1993-09-30 | — | — | WO | disclosed |