Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11044792 | 0.87 | NR3C1 (0.52) | HTR1AHTR2AHTR7DRD3DRD4 | |
| SCHEMBL7294275 | 0.86 | KMT2A (0.58) | HTR1AHTR2AHTR7DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL11041436 | 0.85 | KMT2A (0.57) | HTR1AHTR2AHTR7DRD3DRD4 | |
| SCHEMBL7286669 | 0.85 | HTR1A (0.51) | HTR1AHTR2AHTR7DRD3DRD4 | |
| SCHEMBL7325459 | 0.85 | NR3C1 (0.56) | HTR1AHTR2AHTR7DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL7295612 | 0.83 | KMT2A (0.51) | HTR1AHTR2AHTR7DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL11043902 | 0.83 | KMT2A (0.55) | HTR1AHTR2AHTR7DRD3DRD4 | |
| SCHEMBL11046347 | 0.79 | NR3C1 (0.62) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| Water SCHEMBL11039451 | 0.78 | NR3C1 (0.54) | HTR1AHTR2AHTR7DRD3DRD4 | |
| Iodide SCHEMBL11041065 | 0.78 | NR3C1 (0.61) | NR3C1PGRSLC6A4KCNH2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |