Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MECP2 | P51608 | 1/20 | 0.33 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10618890 | 0.80 | ALDH1A1 (0.40) | KMT2AMEN1GAAHTR3AALDH1A1 | |
| SCHEMBL10618877 | 0.80 | ALDH1A1 (0.40) | KMT2AMEN1GAAHTR3AALDH1A1 | |
| SCHEMBL11125609 | 0.80 | ALDH1A1 (0.40) | KMT2AMEN1GAAALDH1A1MECP2 | |
| SCHEMBL11038980 | 0.77 | ALDH1A1 (0.46) | KMT2AMEN1GAAALDH1A1CYP2C9 | |
| SCHEMBL3256203 | 0.71 | HTR3A (0.41) | KMT2AMEN1GAAHTR3AALDH1A1 | |
| SCHEMBL3256205 | 0.71 | HTR3A (0.41) | KMT2AMEN1GAAHTR3AALDH1A1 | |
| SCHEMBL11039018 | 0.67 | CYP2D6 (0.40) | KMT2AMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL10783623 | 0.65 | MEN1 (0.52) | KMT2AMEN1HTR3AALDH1A1TP53 | |
| SCHEMBL13567612 | 0.63 | ALDH1A1 (0.44) | KMT2AMEN1HTR3AALDH1A1TP53 | |
| SCHEMBL10619002 | 0.63 | ALDH1A1 (0.49) | KMT2AMEN1GAAHTR3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |