Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1946355 | 0.74 | CA2 (0.46) | CA2ALOX5HTTNPC1HPGD | |
| SCHEMBL30464074 | 0.74 | CA2 (0.46) | CA2HTTNPC1HPGDSMN1; SMN2 | |
| SCHEMBL5864109 | 0.74 | CA2 (0.54) | CA2ALOX5HTTALDH1A1 | |
| SCHEMBL11412570 | 0.74 | CA2 (0.48) | CA2HTTSMN1; SMN2LMNAMTNR1A | |
| SCHEMBL25279034 | 0.74 | CA2 (0.46) | CA2HTTNPC1HPGDSMN1; SMN2 | |
| SCHEMBL1081939 | 0.74 | HPGD (0.47) | CA2ALOX5RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL11043380 | 0.71 | HRH3 (0.36) | CA2 | |
| SCHEMBL11429642 | 0.70 | CA2 (0.47) | CA2NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL1567189 | 0.70 | NISCH (0.44) | ALOX5HTTNPC1RAB9ALMNA | |
| SCHEMBL3804776 | 0.69 | ALOX5 (0.52) | CA2ALOX5HTTSMN1; SMN2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |