Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | PPARD | Q03181 | 5/20 | 0.48 |
| ▸ | PPARG | P37231 | 7/20 | 0.47 |
| ▸ | PPARA | Q07869 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11040888 | 0.83 | ALDH1A1 (0.54) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL11038899 | 0.83 | ALDH1A1 (0.54) | ALDH1A1MAPTKDM4EPPARDPPARG | |
| SCHEMBL11041255 | 0.82 | PPARG (0.53) | ALDH1A1MAPTKDM4EPPARDPPARG | |
| SCHEMBL10800272 | 0.81 | PPARG (0.54) | ALDH1A1MAPTKDM4EPPARDPPARG | |
| SCHEMBL11037265 | 0.81 | MAPT (0.61) | ALDH1A1MAPTKDM4EPPARDPPARG | |
| SCHEMBL11040046 | 0.81 | MAPT (0.55) | ALDH1A1MAPTKDM4EPPARDPPARG | |
| SCHEMBL10798526 | 0.81 | PPARG (0.54) | ALDH1A1MAPTKDM4EPPARDPPARG | |
| SCHEMBL11039275 | 0.81 | PPARG (0.52) | ALDH1A1MAPTKDM4EPPARDPPARG | |
| SCHEMBL11037795 | 0.79 | ALDH1A1 (0.59) | ALDH1A1MAPTKDM4EPPARDPPARG | |
| SCHEMBL10796552 | 0.78 | PPARG (0.57) | ALDH1A1MAPTKDM4EPPARDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |
| EP-0061425-A2 | Thiazole derivatives, processes for their preparation, medicaments containing them and their use | CIBA-GEIGY AG (CH) | 1982-09-29 | — | — | EP | disclosed |