Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236368 | 0.83 | FYN (0.51) | DYRK1APIK3CAAKT1MTORPIK3CG | |
| SCHEMBL18134782 | 0.82 | DYRK1A (0.67) | DYRK1APIK3CAAKT1MTORPIK3CG | |
| SCHEMBL3263422 | 0.81 | DYRK1A (0.49) | DYRK1APIK3CAAKT1MTORPIK3CG | |
| SCHEMBL754222 | 0.81 | DYRK1A (0.45) | DYRK1APIK3CAAKT1MTORPIK3CG | |
| SCHEMBL798566 | 0.78 | PIK3CG (0.50) | DYRK1APIK3CAAKT1MTORPIK3CG | |
| SCHEMBL3264279 | 0.74 | ALDH1A3 (0.49) | DYRK1APIK3CAPIK3CGPIK3CD | |
| SCHEMBL12673618 | 0.73 | FYN (0.51) | — | |
| SCHEMBL12909569 | 0.72 | PIK3CG (0.59) | DYRK1APIK3CAMTORPIK3CGPIK3CD | |
| Hydrochloric Acid SCHEMBL938808 | 0.71 | PIK3CG (0.58) | DYRK1APIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL3232733 | 0.71 | BRD4 (0.53) | PIK3CAPIK3CGPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | AMGEN INC. (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | PIK3CA, PIKFYVE, PIK3CD | DYRK1A 1062/4885PIK3CA 1/4885AKT1 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.