Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 3/20 | 0.50 |
| ▸ | FYN | P06241 | 4/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12664018 | 0.83 | TP53 (0.50) | PIK3CGFYNDYRK1A | |
| SCHEMBL3264279 | 0.82 | ALDH1A3 (0.49) | PIK3CGPIK3CADYRK1APIK3CD | |
| SCHEMBL3711935 | 0.78 | PIK3CG (0.63) | PIK3CGPIK3CACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL11043630 | 0.78 | DYRK1A (0.45) | PIK3CGPIK3CAAKT1MTORDYRK1A | |
| SCHEMBL31483039 | 0.78 | PIK3CA (0.61) | PIK3CGPIK3CAAKT1MTORPIK3CD | |
| SCHEMBL3232733 | 0.76 | BRD4 (0.53) | PIK3CGFYNPIK3CAPIK3CDPIK3CB | |
| SCHEMBL12664447 | 0.76 | PIK3CG (0.55) | PIK3CGFYNPIK3CACYP3A4PIK3CD | |
| SCHEMBL13188559 | 0.76 | FYN (0.56) | FYNPIK3CA | |
| SCHEMBL799204 | 0.75 | PIK3CG (0.53) | PIK3CGFYNPIK3CAPIK3CD | |
| SCHEMBL3236368 | 0.74 | FYN (0.51) | PIK3CGFYNPIK3CACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-03-22 | — | — | US | disclosed |
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | MTOR, STAT3, SLC14A1 | PIK3CG 16/4885FYN 1850/4885PIK3CA 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.