SCHEMBL11044578

SCHEMBL11044578

O=C(c1ccc(Cl)cc1)C(Oc1ccc(Cl)cc1)n1ccnc1

nearest known ligand 0.69

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.69
MEN1 O00255 1/20 0.69
ADORA3 P0DMS8 1/20 0.69
CHRM1 P11229 1/20 0.69
SLC6A2 P23975 1/20 0.69
SLC6A4 P31645 1/20 0.69
ADRA1A P35348 1/20 0.69
SLC6A3 Q01959 1/20 0.69
KMT2A Q03164 1/20 0.69
CYP19A1 P11511 4/20 0.48
CYP26A1 O43174 2/20 0.45
CYP24A1 Q07973 3/20 0.43
CYP27B1 O15528 2/20 0.43
TBXAS1 P24557 2/20 0.39
TBXA2R P21731 2/20 0.38
PKM P14618 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11427370 0.83 MEN1 (0.51) CYP3A4MEN1ADORA3CHRM1SLC6A2
Hydrochloric Acid SCHEMBL11484649 0.83 CYP3A4 (0.61) CYP3A4MEN1ADORA3CHRM1SLC6A2
Climbazole SCHEMBL4405250 0.82 CYP3A4 (1.00) CYP3A4MEN1ADORA3CHRM1SLC6A2
Climbazole SCHEMBL4879119 0.82 CYP3A4 (1.00) CYP3A4MEN1ADORA3CHRM1SLC6A2
Climbazole SCHEMBL39729 0.82 CYP3A4 (1.00) CYP3A4MEN1ADORA3CHRM1SLC6A2
Climbazole SCHEMBL6235296 0.82 CYP3A4 (1.00) CYP3A4MEN1ADORA3CHRM1SLC6A2
Climbazole SCHEMBL23779989 0.81 CYP3A4 (0.97) CYP3A4MEN1ADORA3CHRM1SLC6A2
Climbazole SCHEMBL20504618 0.81 CYP3A4 (0.97) CYP3A4MEN1ADORA3CHRM1SLC6A2
SCHEMBL11004254 0.79 CYP3A4 (0.80) CYP3A4MEN1ADORA3CHRM1SLC6A2
Climbazole SCHEMBL28715628 0.79 CYP3A4 (0.93) CYP3A4MEN1ADORA3CHRM1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0027177-B1 1-AZOLYL-1-HALOGEN-ALKAN-2-ONES AND PROCESS FOR THE PREPARATION OF 1-AZOLYL-1-PHENOXY-ALKAN-2-ONES BAYER AG (DE) 1984-05-02 EP disclosed