Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 6/20 | 0.59 |
| ▸ | DRD3 | P35462 | 6/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11041972 | 0.99 | KCNA5 (0.61) | KCNA5MEN1KMT2ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL11044917 | 0.94 | DRD2 (0.57) | KCNA5MEN1KMT2ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL11045592 | 0.93 | DRD2 (0.61) | KCNA5MEN1KMT2ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL11041142 | 0.92 | DRD2 (0.60) | KCNA5DRD2DRD3HTR2A | |
| Hydrochloric Acid SCHEMBL11042505 | 0.92 | KCNA5 (0.60) | KCNA5MEN1KMT2ADRD2DRD3 | |
| SCHEMBL9825173 | 0.91 | KCNA5 (0.64) | KCNA5MEN1KMT2ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL11042650 | 0.89 | DRD3 (0.66) | KCNA5DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL11048474 | 0.89 | KMT2A (0.54) | KCNA5MEN1KMT2ADRD2DRD3 | |
| SCHEMBL7346182 | 0.88 | GRIN2B (0.56) | KCNA5MEN1KMT2ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL11042167 | 0.84 | DRD2 (0.55) | KCNA5DRD2DRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | claimed |
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |