SCHEMBL11045702

SCHEMBL11045702

C=CCc1ccc(N)c(C#N)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.43
GABRA1 P14867 6/20 0.42
GABRB2 P47870 6/20 0.42
ALDH1A1 P00352 5/20 0.42
MAPT P10636 4/20 0.42
MEN1 O00255 3/20 0.42
GAA P10253 3/20 0.42
CNR2 P34972 3/20 0.42
KMT2A Q03164 3/20 0.42
PPARG P37231 2/20 0.42
PPARD Q03181 2/20 0.42
CNR1 P21554 2/20 0.42
KDM4E B2RXH2 2/20 0.42
ALDH2 P05091 1/20 0.42
AKR1B1 P15121 1/20 0.42
HPGD P15428 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
PPARA Q07869 1/20 0.40
CYP3A4 P08684 4/20 0.39
CYP1A2 P05177 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11623855 0.86 XDH (0.43) XDHGABRA1GABRB2ALDH1A1MAPT
SCHEMBL2641095 0.83 ALDH1A1 (0.47) XDHGABRA1GABRB2ALDH1A1MAPT
SCHEMBL9747999 0.79 TP53 (0.35) XDHGABRA1GABRB2ALDH1A1MAPT
SCHEMBL11057646 0.79 CYP3A4 (0.48) ALDH1A1MAPTMEN1GAAKMT2A
SCHEMBL2656097 0.79 XDH (0.43) XDHGABRA1GABRB2ALDH1A1MAPT
SCHEMBL10974908 0.79 XDH (0.61) XDHGABRA1GABRB2ALDH1A1MAPT
SCHEMBL8655177 0.77 XDH (0.52) XDHGABRA1GABRB2ALDH1A1MAPT
SCHEMBL2164753 0.76 XDH (0.44) XDHGABRA1GABRB2ALDH1A1MAPT
SCHEMBL13226789 0.76 CYP2A6 (0.47) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL1739243 0.75 ALDH1A1 (0.43) XDHGABRA1GABRB2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59144749-A None JP disclosed
JP-S59144749-A SCHIFF BASE HAVING MEGATIVE DIELECTRIC ANISOTROPY CHISSO CORP 1984-08-18 JP disclosed