Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 5/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690847 | 0.81 | APLNR (0.41) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL28918296 | 0.78 | APLNR (0.40) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL2279581 | 0.76 | MEN1 (0.39) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL28682013 | 0.76 | DGAT1 (0.45) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL28672286 | 0.76 | MEN1 (0.39) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL5007482 | 0.76 | MEN1 (0.39) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL7279185 | 0.76 | MEN1 (0.39) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL2274474 | 0.76 | DGAT1 (0.41) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL28682014 | 0.76 | DGAT1 (0.45) | APLNRTDP1CA1CA2CA7 | |
| SCHEMBL8353864 | 0.74 | APLNR (0.38) | APLNRTDP1CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0098457-A2 | (1S,2R,3R)- and (1R,2S,3S)-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes useful in the total synthesis of cyclosporins and processes for their production | SANDOZ AG (CH) | 1984-01-18 | — | — | EP | disclosed |
| EP-0098456-A2 | Peptides comprising a (1S,2R,3R)- or (1R,2S,3S)-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptane or -hept-5-ene residue useful in the total synthesis of cyclosporins, and processes for their production | SANDOZ AG (CH) | 1984-01-18 | — | — | EP | disclosed |
| EP-0034567-A2 | A method for the total synthesis of cyclosporins and novel cyclosporins | SANDOZ AG (CH) | 1981-08-26 | — | — | EP | disclosed |