Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11045918 | 1.00 | HSD11B1 (0.51) | HSD11B1JAK2JAK1AGTR2POLB | |
| SCHEMBL26966069 | 0.89 | HSD11B1 (0.52) | HSD11B1JAK2JAK1AGTR2CETP | |
| SCHEMBL26966070 | 0.89 | HSD11B1 (0.48) | HSD11B1JAK2JAK1AGTR2CETP | |
| SCHEMBL26966018 | 0.87 | HSD11B1 (0.47) | HSD11B1JAK2JAK1AGTR2CETP | |
| SCHEMBL13841899 | 0.84 | HSD11B1 (0.45) | HSD11B1JAK2JAK1AGTR2CETP | |
| SCHEMBL2820222 | 0.84 | HSD11B1 (0.45) | HSD11B1JAK2JAK1AGTR2CETP | |
| SCHEMBL20299758 | 0.83 | HSD11B1 (0.48) | HSD11B1JAK2JAK1AGTR2CETP | |
| SCHEMBL13841892 | 0.82 | HSD11B1 (0.52) | HSD11B1JAK2JAK1AGTR2CETP | |
| SCHEMBL2824379 | 0.82 | HSD11B1 (0.52) | HSD11B1JAK2JAK1AGTR2CETP | |
| SCHEMBL21285790 | 0.81 | FKBP1A (0.42) | HSD11B1JAK2JAK1AGTR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4462943-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-07-31 | — | — | US | disclosed |
| EP-0052991-A1 | Carboxyalkyl amino acid derivatives of various substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-06-02 | — | — | EP | disclosed |