Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.53 |
| ▸ | NEK2 | P51955 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11044692 | 0.83 | NR1I2 (0.46) | NR1I2NEK2KMT2AMEN1POLB | |
| SCHEMBL11045371 | 0.83 | NR1I2 (0.50) | NR1I2NEK2KMT2AMEN1NPSR1 | |
| SCHEMBL11045403 | 0.82 | NR1I2 (0.45) | NR1I2NPSR1ALDH1A1MAPTHPGD | |
| SCHEMBL11040968 | 0.81 | NR1I2 (0.46) | NR1I2POLBALDH1A1L3MBTL1 | |
| SCHEMBL12270060 | 0.80 | NR1I2 (0.82) | NR1I2NEK2TP53EEDKMT2A | |
| SCHEMBL11041665 | 0.75 | NR1I2 (0.46) | NR1I2KMT2AMEN1POLBLMNA | |
| SCHEMBL11042702 | 0.75 | NR1I2 (0.44) | NR1I2KMT2APOLBNPSR1LMNA | |
| Biphenyl SCHEMBL28234426 | 0.75 | POLB (0.50) | NR1I2KMT2AMEN1POLBNPSR1 | |
| SCHEMBL12270096 | 0.73 | NR1I2 (0.54) | NR1I2NEK2TP53EEDKMT2A | |
| SCHEMBL11048410 | 0.73 | NR1I2 (0.42) | NR1I2KMT2AMEN1POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4473560-A | Diphosphonic acid derivatives and pharmaceutical preparations containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-09-25 | — | — | US | disclosed |