Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11045811 | 0.92 | ACE (0.41) | MAPK1ACENOTUMKMT2A | |
| SCHEMBL11045822 | 0.90 | MEN1 (0.43) | MAPK1ACEKMT2A | |
| SCHEMBL11051577 | 0.87 | ACE (0.47) | ACE | |
| SCHEMBL11052121 | 0.84 | MEN1 (0.38) | ACEKMT2A | |
| SCHEMBL11049699 | 0.82 | ACE (0.42) | MAPK1ACE | |
| SCHEMBL11046009 | 0.81 | MEN1 (0.36) | MAPK1NOTUMKMT2A | |
| SCHEMBL11046064 | 0.80 | ACE (0.42) | MAPK1ACENOTUM | |
| SCHEMBL11047965 | 0.77 | ACE (0.55) | ACE | |
| SCHEMBL11043199 | 0.77 | ACE (0.55) | ACE | |
| SCHEMBL11050573 | 0.77 | KMT2A (0.49) | ACEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4461896-A | 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1984-07-24 | — | — | US | disclosed |