Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11045822 | 0.91 | MEN1 (0.43) | ACEMAPK1 | |
| SCHEMBL11043214 | 0.91 | ACE (0.42) | ACEMAPK1 | |
| SCHEMBL11049699 | 0.89 | ACE (0.42) | ACEMAPK1 | |
| SCHEMBL11045811 | 0.88 | ACE (0.41) | ACEMAPK1NOTUM | |
| SCHEMBL11047965 | 0.85 | ACE (0.55) | ACE | |
| SCHEMBL11043199 | 0.85 | ACE (0.55) | ACE | |
| SCHEMBL11052441 | 0.84 | ACE (0.54) | ACE | |
| SCHEMBL11052446 | 0.84 | ACE (0.54) | ACE | |
| SCHEMBL11052121 | 0.83 | MEN1 (0.38) | ACE | |
| SCHEMBL11045824 | 0.82 | MEN1 (0.36) | ACEMAPK1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4461896-A | 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1984-07-24 | — | — | US | claimed |
| US-4461896-A | 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1984-07-24 | — | — | US | disclosed |