SCHEMBL11046044

SCHEMBL11046044

C=CC(C)(Cc1ccccc1)C(C)=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.53
CYP3A4 P08684 2/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.43
HIF1A Q16665 1/20 0.43
SLC6A2 P23975 1/20 0.42
TAAR1 Q96RJ0 1/20 0.42
THRA P10827 1/20 0.41
THRB P10828 1/20 0.41
LMNA P02545 2/20 0.40
CYP2D6 P10635 1/20 0.40
MMP8 P22894 4/20 0.40
RECQL P46063 2/20 0.40
CYP1A2 P05177 1/20 0.40
TRPA1 O75762 1/20 0.40
PPARG P37231 1/20 0.39
PPARA Q07869 1/20 0.39
MAPK1 P28482 1/20 0.39
FDPS P14324 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26654265 0.87 ALDH1A1 (0.54) ALDH1A1CYP3A4CYP2C9CYP2C19SMN1; SMN2
SCHEMBL6667248 0.87 ALDH1A1 (0.54) ALDH1A1CYP3A4CYP2C9CYP2C19SMN1; SMN2
SCHEMBL11037283 0.84 ALDH1A1 (0.47) ALDH1A1CYP3A4CYP2C9CYP2C19SMN1; SMN2
SCHEMBL11037284 0.84 ALDH1A1 (0.47) ALDH1A1CYP3A4CYP2C9CYP2C19SMN1; SMN2
SCHEMBL11039404 0.83 SLC6A4 (0.46) ALDH1A1CYP3A4CYP2C9CYP2C19SMN1; SMN2
SCHEMBL11046066 0.83 CYP3A4 (0.50) ALDH1A1CYP3A4CYP2C9CYP2C19SMN1; SMN2
SCHEMBL28904910 0.81 CYP3A4 (0.49) ALDH1A1CYP3A4CYP2C9CYP2C19SMN1; SMN2
SCHEMBL11039805 0.80 SMN1; SMN2 (0.46) ALDH1A1CYP3A4SMN1; SMN2HIF1ATHRA
SCHEMBL6834512 0.80 ALDH1A1 (0.50) ALDH1A1CYP3A4CYP2C9CYP2C19SMN1; SMN2
SCHEMBL14498573 0.76 ALDH1A1 (0.50) ALDH1A1CYP3A4CYP2C9CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0038471-B1 BETA-GAMMA-UNSATURATED KETONES AND ISOPRENOIC DIENONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PERFUME COMPOUNDS AND FLAVOURINGS Consortium für elektrochemische Industrie GmbH (DE) 1984-11-14 EP disclosed
US-4385185-A β-γ-Unsaturated ketones and isoprenoid 2,6 diones, a process for producing the same and their use as fragrant and flavoring substances CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1983-05-24 US disclosed
EP-0038471-A1 Beta-gamma-unsaturated ketones and isoprenoic dienones, process for their preparation and their use as perfume compounds and flavourings Consortium für elektrochemische Industrie GmbH (DE) 1981-10-28 EP disclosed