SCHEMBL11039404

SCHEMBL11039404

C=CC(C)(Cc1ccc(Cl)cc1)C(C)=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 2/20 0.46
SLC6A2 P23975 1/20 0.46
HTR2A P28223 1/20 0.46
HRH1 P35367 1/20 0.46
HTR2B P41595 1/20 0.46
CHRNA4 P43681 1/20 0.46
SLC6A3 Q01959 1/20 0.46
CYP3A4 P08684 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP1A2 P05177 2/20 0.43
CYP2C19 P33261 2/20 0.43
CYP2D6 P10635 1/20 0.43
NFKB1 P19838 1/20 0.43
THRA P10827 1/20 0.42
THRB P10828 1/20 0.42
LMNA P02545 3/20 0.42
PMP22 Q01453 1/20 0.42
NLRP3 Q96P20 1/20 0.42
PPARG P37231 1/20 0.40
PPARA Q07869 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11046044 0.83 ALDH1A1 (0.53) SLC6A2CYP3A4CYP2C9CYP1A2CYP2C19
SCHEMBL11043463 0.83 FDPS (0.45) THRATHRBMEN1KMT2ASMN1; SMN2
SCHEMBL11039805 0.81 SMN1; SMN2 (0.46) CYP3A4THRATHRBL3MBTL1ALDH1A1
SCHEMBL11039015 0.78 L3MBTL1 (0.41) SLC6A4SLC6A2HTR2AHRH1HTR2B
SCHEMBL10383881 0.77 SLC6A4 (0.53) SLC6A4SLC6A2HTR2AHRH1HTR2B
SCHEMBL8161806 0.75 THRA (0.47) SLC6A4SLC6A2HTR2AHRH1HTR2B
SCHEMBL18230874 0.74 SLC6A4 (0.55) SLC6A4SLC6A2HTR2AHRH1HTR2B
SCHEMBL9479412 0.72 SLC6A4 (0.61) SLC6A4SLC6A2HTR2AHRH1HTR2B
SCHEMBL24917189 0.71 SLC6A4 (0.47) SLC6A4SLC6A2HTR2AHRH1HTR2B
SCHEMBL7873834 0.71 CYP3A4 (0.72) SLC6A4SLC6A2HTR2AHRH1HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0038471-B1 BETA-GAMMA-UNSATURATED KETONES AND ISOPRENOIC DIENONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PERFUME COMPOUNDS AND FLAVOURINGS Consortium für elektrochemische Industrie GmbH (DE) 1984-11-14 EP disclosed
US-4385185-A β-γ-Unsaturated ketones and isoprenoid 2,6 diones, a process for producing the same and their use as fragrant and flavoring substances CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1983-05-24 US disclosed
EP-0038471-A1 Beta-gamma-unsaturated ketones and isoprenoic dienones, process for their preparation and their use as perfume compounds and flavourings Consortium für elektrochemische Industrie GmbH (DE) 1981-10-28 EP disclosed