Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CTSV | O60911 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.35 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.34 |
| ▸ | AGXT | P21549 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27740112 | 0.80 | TSHR (0.41) | TSHRIDO1ALDH1A1AGXT | |
| SCHEMBL28208353 | 0.72 | PDPK1 (0.40) | TSHRIDO1PDPK1MTOR | |
| SCHEMBL10592407 | 0.69 | OPRM1 (0.44) | OPRM1OPRL1TSHRIDO1ALDH1A1 | |
| SCHEMBL13996381 | 0.69 | PDPK1 (0.46) | OPRM1OPRL1TSHRIDO1ALDH1A1 | |
| SCHEMBL3856170 | 0.69 | PDPK1 (0.46) | OPRM1OPRL1TSHRIDO1ALDH1A1 | |
| SCHEMBL29552477 | 0.67 | TSHR (0.43) | OPRM1OPRL1TSHRIDO1ALDH1A1 | |
| SCHEMBL14303446 | 0.67 | OPRM1 (0.45) | OPRM1OPRL1TSHRIDO1ALDH1A1 | |
| SCHEMBL22594119 | 0.67 | OPRM1 (0.53) | OPRM1OPRL1TSHRIDO1ALDH1A1 | |
| SCHEMBL7294202 | 0.67 | TSHR (0.43) | OPRM1OPRL1TSHRIDO1ALDH1A1 | |
| SCHEMBL14094693 | 0.67 | GSTP1 (0.51) | OPRM1OPRL1TSHRIDO1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0098456-A2 | Peptides comprising a (1S,2R,3R)- or (1R,2S,3S)-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptane or -hept-5-ene residue useful in the total synthesis of cyclosporins, and processes for their production | SANDOZ AG (CH) | 1984-01-18 | — | — | EP | disclosed |
| EP-0034567-A2 | A method for the total synthesis of cyclosporins and novel cyclosporins | SANDOZ AG (CH) | 1981-08-26 | — | — | EP | disclosed |