Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.43 |
| ▸ | HTR3B | O95264 | 3/20 | 0.43 |
| ▸ | HTR3A | P46098 | 3/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1104767 | 0.90 | KDM4E (0.56) | ALDH1A1KDM4EHPGDHSD17B10TGFBR1 | |
| SCHEMBL1104770 | 0.76 | HTR2C (0.46) | ALDH1A1KDM4EHTR3EHTR3BHTR3A | |
| SCHEMBL204292 | 0.75 | KDM4E (0.47) | ALDH1A1KDM4EHPGDHSD17B10TGFBR1 | |
| SCHEMBL839645 | 0.75 | KDM4E (0.61) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL31249024 | 0.75 | KDM4E (0.61) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL1104773 | 0.71 | ALDH1A1 (0.39) | ALDH1A1KDM4EHSD17B10TGFBR1HTR3E | |
| SCHEMBL202005 | 0.70 | KDM4E (0.42) | ALDH1A1KDM4EHPGDHSD17B10TGFBR1 | |
| SCHEMBL2743292 | 0.70 | KDM4E (0.58) | ALDH1A1KDM4EHPGDHSD17B10TGFBR1 | |
| SCHEMBL10824587 | 0.70 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL1104755 | 0.69 | KDM4E (0.51) | ALDH1A1KDM4EHPGDHSD17B10TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420817-B2 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2013-04-16 | — | — | US | disclosed |
| US-20120165531-A1 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2012-06-28 | — | — | US | disclosed |
| US-8153796-B2 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2012-04-10 | — | — | US | disclosed |
| US-20100173929-A1 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173929-A1 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | ZDHHC7, CNR2, HDAC3 | ALDH1A1 1200/4885KDM4E 2247/4885HPGD 2327/4885 |
| US-20120165531-A1 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | ZDHHC7, CNR2, HDAC3 | ALDH1A1 1200/4885KDM4E 2247/4885HPGD 2327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.