Sugi Predict

Sugi Predict / Compounds / SCHEMBL202005

SCHEMBL202005

SCHEMBL202005

Nc1nc2cccnc2c2c1nc1n2CCN1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.42
▸ ALDH1A1 P00352 3/20 0.42
▸ HPGD P15428 2/20 0.42
▸ HSD17B10 Q99714 2/20 0.42
▸ PRMT5 O14744 1/20 0.39
▸ HRH4 Q9H3N8 1/20 0.39
▸ TGFBR1 P36897 3/20 0.37
▸ POLB P06746 1/20 0.35
▸ PIK3CD O00329 4/20 0.34
▸ HTR2A P28223 1/20 0.34
▸ HTR2C P28335 1/20 0.34
▸ SLC6A4 P31645 1/20 0.34
▸ MAPK10 P53779 1/20 0.34
▸ PIK3CA P42336 3/20 0.34
▸ PIK3CG P48736 3/20 0.34
▸ MTOR P42345 2/20 0.34
▸ PARP1 P09874 2/20 0.33
▸ CDK1 P06493 1/20 0.33
▸ CDK2 P24941 1/20 0.33
▸ MKNK1 Q9BUB5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL204292 0.78 KDM4E (0.47) KDM4EALDH1A1HPGDHSD17B10HRH4
SCHEMBL203999 0.75 KDM4E (0.58) KDM4EALDH1A1HPGDHSD17B10POLB
SCHEMBL12165325 0.73 PIK3CD (0.42) KDM4EALDH1A1HPGDHSD17B10PRMT5
SCHEMBL1104756 0.70 ALDH1A1 (0.54) KDM4EALDH1A1HPGDHSD17B10HRH4
SCHEMBL10123111 0.69 PRMT5 (0.50) KDM4EALDH1A1PRMT5HRH4POLB
SCHEMBL203433 0.69 PRMT5 (0.40) PRMT5HRH4CDK1CDK2MKNK1
SCHEMBL4299811 0.68 TLR7 (0.42) KDM4EALDH1A1HPGDHSD17B10PRMT5
SCHEMBL204390 0.68 PRMT5 (0.42) KDM4EALDH1A1HPGDHSD17B10PRMT5
SCHEMBL1232669 0.67 HRH4 (0.37) KDM4EALDH1A1HPGDHSD17B10PRMT5
SCHEMBL30576164 0.67 HTR2C (0.51) KDM4EALDH1A1HPGDHSD17B10HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8088788-B2 Substituted fused[1,2] imidazo[4,5-c] ring compounds and methods 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-01-03 — — US disclosed
US-8088788-B2 Substituted fused[1,2] imidazo[4,5-c] ring compounds and methods 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-01-03 — — US disclosed
US-8088788-B2 Substituted fused[1,2] imidazo[4,5-c] ring compounds and methods 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-01-03 — — US disclosed
US-20090221551-A1 SUBSTITUTED FUSED[1,2] IMIDAZO[4,5C] RING COMPOUNDS AND METHODS PFIZER INC. 2009-09-03 — — US disclosed
US-20090221551-A1 SUBSTITUTED FUSED[1,2] IMIDAZO[4,5C] RING COMPOUNDS AND METHODS PFIZER INC. 2009-09-03 — — US disclosed
US-20090221551-A1 SUBSTITUTED FUSED[1,2] IMIDAZO[4,5C] RING COMPOUNDS AND METHODS PFIZER INC. 2009-09-03 — — US disclosed
WO-2007106852-A2 SUBSTITUTED FUSED[1,2]IMIDAZO[4,5-C] RING COMPOUNDS AND METHODS COLEY PHARMACEUTICAL GROUP, INC. (US) 2007-09-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090221551-A1 SUBSTITUTED FUSED[1,2] IMIDAZO[4,5C] RING COMPOUNDS AND METHODS IL2, IFNG, IL4 KDM4E 2419/4885ALDH1A1 979/4885HPGD 235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.