Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.46 |
| ▸ | DBH | P09172 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38652180 | 1.00 | KDM4E (0.56) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C19 | |
| Ethoxycarbonyl Group SCHEMBL27894613 | 0.86 | KDM4E (0.47) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9278020 | 0.84 | TP53 (0.45) | KDM4ECYP1A2CYP2C19MAPTCYP11B1 | |
| SCHEMBL30828413 | 0.83 | ATM (0.57) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL38652459 | 0.83 | HTT (0.56) | KDM4EMAPTCYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL38652062 | 0.82 | KMT2A (0.49) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL324010 | 0.82 | KMT2A (0.49) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3537897 | 0.80 | LPO (0.55) | KDM4ECYP1A2CYP3A4CYP2C19MAPT | |
| SCHEMBL16035284 | 0.79 | STAT6 (0.45) | CYP11B1CYP11B2ALDH1A1STAT6DBH | |
| SCHEMBL29643774 | 0.78 | PTK2 (0.49) | KDM4EATMCYP11B1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420817-B2 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2013-04-16 | — | — | US | disclosed |
| US-20120165531-A1 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2012-06-28 | — | — | US | disclosed |
| US-8153796-B2 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2012-04-10 | — | — | US | disclosed |
| US-20100173929-A1 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173929-A1 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | ZDHHC7, CNR2, HDAC3 | KDM4E 2247/4885CYP1A2 42/4885CYP3A4 31/4885 |
| US-20120165531-A1 | Tricyclic N-heteroaryl-carboxamide derivatives, preparation and therapeutic use thereof | ZDHHC7, CNR2, HDAC3 | KDM4E 2247/4885CYP1A2 42/4885CYP3A4 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.