Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bendacalol SCHEMBL11050612 | 0.98 | LMNA (0.51) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| Bendacalol SCHEMBL588993 | 0.92 | LMNA (0.52) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| Bendacalol SCHEMBL29400550 | 0.92 | LMNA (0.52) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL7441442 | 0.88 | LMNA (0.50) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| Hydrochloric Acid SCHEMBL11044563 | 0.87 | POLB (0.50) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL11112393 | 0.85 | HPGD (0.48) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL11053241 | 0.84 | LMNA (0.43) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL7434948 | 0.83 | LMNA (0.51) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL11055545 | 0.82 | LMNA (0.50) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL11279575 | 0.82 | LMNA (0.50) | LMNAMAPTSMN1; SMN2NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471128-A | 1,5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | claimed |
| US-4471127-A | 1-5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | claimed |
| EP-0050585-A1 | 1,5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5 diols, process for their preparation, pharmaceutical preparations containing them and their therapeutical use | CIBA-GEIGY AG (CH) | 1982-04-28 | — | — | EP | claimed |
| US-4313955-A | HYPOTESIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1982-02-02 | — | — | US | claimed |
| US-20220047505-A1 | Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration | STI PHARMA, LLC (US) | 2022-02-17 | — | — | US | disclosed |
| EP-0050585-B1 | 1,5-BIS-(1,4-BENZODIOXIN-2-YL)-3-AZAPENTANE-1,5 DIOLS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR THERAPEUTICAL USE | CIBA-GEIGY AG (CH) | 1984-10-03 | — | — | EP | disclosed |
| US-4471127-A | 1-5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |
| US-4471127-A | 1-5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |
| US-4471128-A | 1,5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |
| US-4471128-A | 1,5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |
| US-4380653-A | HYPOTENSIVES, CARDIOVASCULAR DISORDERS | CIBA-GEIGY CORPORATION (US) | 1983-04-19 | — | — | US | disclosed |
| US-4380653-A | HYPOTENSIVES, CARDIOVASCULAR DISORDERS | CIBA-GEIGY CORPORATION (US) | 1983-04-19 | — | — | US | disclosed |
| US-4313955-A | HYPOTESIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1982-02-02 | — | — | US | disclosed |
| US-4313955-A | HYPOTESIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1982-02-02 | — | — | US | disclosed |