Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11055545 | 0.85 | LMNA (0.50) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL11055550 | 0.85 | LMNA (0.50) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL11279575 | 0.85 | LMNA (0.50) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL10991807 | 0.85 | LMNA (0.50) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL7434736 | 0.85 | LMNA (0.50) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL7443199 | 0.85 | LMNA (0.50) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| Hydrochloric Acid SCHEMBL7437739 | 0.83 | LMNA (0.49) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| Bendacalol SCHEMBL11047717 | 0.83 | LMNA (0.52) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| Bendacalol SCHEMBL11050612 | 0.82 | LMNA (0.51) | LMNAMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL10832049 | 0.81 | LMNA (0.50) | LMNAMAPTSMN1; SMN2NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |