Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11047938 | 0.88 | SLC6A3 (0.72) | SLC6A3SIGMAR1SLC6A2SLC6A4CYP2D6 | |
| SCHEMBL142605 | 0.85 | SLC6A3 (0.77) | SLC6A3SIGMAR1SLC6A2SLC6A4CYP2D6 | |
| SCHEMBL140633 | 0.85 | SLC6A3 (0.68) | SLC6A3SIGMAR1SLC6A2SLC6A4CYP2D6 | |
| SCHEMBL10831116 | 0.82 | SIGMAR1 (0.71) | SLC6A3SIGMAR1HTR2C | |
| SCHEMBL145634 | 0.80 | SLC6A3 (0.66) | SLC6A3SIGMAR1SLC6A2SLC6A4CYP2D6 | |
| SCHEMBL11046164 | 0.80 | SLC6A3 (0.66) | SLC6A3SIGMAR1SLC6A2SLC6A4CYP2D6 | |
| SCHEMBL20250240 | 0.80 | SLC6A2 (0.46) | SLC6A3SLC6A2SLC6A4CYP2D6HTR2C | |
| SCHEMBL15433977 | 0.80 | SLC6A2 (0.64) | SLC6A3SLC6A2SLC6A4CYP2D6HTR2C | |
| SCHEMBL10830294 | 0.79 | SLC6A3 (0.61) | SLC6A3SIGMAR1SLC6A2SLC6A4CYP2D6 | |
| SCHEMBL141031 | 0.78 | SLC6A2 (0.58) | SLC6A3SIGMAR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478836-A | 1-Aryl 2-aminomethyl cyclopropane carboxyamide (Z) derivatives and their use as useful drugs in the treatment of disturbances of the central nervous system | PIERRE FABRE S.A. (FR) | 1984-10-23 | — | — | US | disclosed |