SCHEMBL1104890

SCHEMBL1104890

COC(=O)/C(=C/c1cccc([N+](=O)[O-])c1)OC

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLO1 Q04760 2/20 0.61
FBP1 P09467 1/20 0.55
KMT2A Q03164 3/20 0.54
LMNA P02545 2/20 0.54
KDM4E B2RXH2 1/20 0.54
ALDH1A1 P00352 1/20 0.54
NFE2L2 Q16236 3/20 0.51
MAPT P10636 3/20 0.51
TRPV1 Q8NER1 2/20 0.49
RAB9A P51151 2/20 0.49
NPC1 O15118 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
MEN1 O00255 2/20 0.49
CYP1A2 P05177 2/20 0.48
CYP3A4 P08684 2/20 0.48
CYP2C19 P33261 1/20 0.48
TXNRD1 Q16881 1/20 0.48
TXNRD3 Q86VQ6 1/20 0.48
TXNRD2 Q9NNW7 1/20 0.48
HIF1A Q16665 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1094958 1.00 GLO1 (0.61) GLO1FBP1KMT2ALMNAKDM4E
SCHEMBL1094959 1.00 GLO1 (0.61) GLO1FBP1KMT2ALMNAKDM4E
SCHEMBL1104866 0.89 GLO1 (0.61) GLO1FBP1KMT2ALMNAKDM4E
SCHEMBL1095397 0.89 GLO1 (0.61) GLO1FBP1KMT2ALMNAKDM4E
SCHEMBL1095398 0.89 GLO1 (0.61) GLO1FBP1KMT2ALMNAKDM4E
SCHEMBL7265045 0.88 GLO1 (0.73) GLO1FBP1KMT2ALMNAKDM4E
SCHEMBL17392023 0.84 GLO1 (0.59) GLO1FBP1KMT2ALMNAKDM4E
SCHEMBL17392025 0.84 GLO1 (0.59) GLO1FBP1KMT2ALMNAKDM4E
SCHEMBL9667966 0.83 GLO1 (0.79) GLO1FBP1KMT2ALMNAKDM4E
SCHEMBL6271817 0.83 GLO1 (0.79) GLO1FBP1KMT2ALMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10016381-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2018-07-10 US disclosed
US-20170312239-A1 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD GIULIANI INTERNATIONAL LIMITED (IE) 2017-11-02 US disclosed
US-20170312239-A1 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD GIULIANI INTERNATIONAL LIMITED (IE) 2017-11-02 US disclosed
US-9561202-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2017-02-07 US disclosed
US-9561202-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2017-02-07 US disclosed
US-9345680-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2016-05-24 US disclosed
US-9345680-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2016-05-24 US disclosed
US-20150265563-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2015-09-24 US disclosed
US-20150265562-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2015-09-24 US disclosed
US-20150265563-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2015-09-24 US disclosed
US-20150265562-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2015-09-24 US disclosed
US-20150045436-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field NOGRA PHARMA LIMITED (IE) 2015-02-12 US disclosed
US-20150045436-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field NOGRA PHARMA LIMITED (IE) 2015-02-12 US disclosed
US-8710100-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2014-04-29 US disclosed
US-8710100-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2014-04-29 US disclosed
US-20130005813-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2013-01-03 US disclosed
US-20130005813-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2013-01-03 US disclosed
US-8153841-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field GIULIANI INTERNATIONAL LIMITED (IE) 2012-04-10 US disclosed
US-20090048343-A1 Compounds and Their Salts Specific to the PPAR Receptors and the EGF Receptors and Their Use in the Medical Field NOGRA PHARMA LIMITED (IE) 2009-02-19 US disclosed
WO-2007010516-A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD GIULIANI INTERNATIONAL LIMITED (IE) 2007-01-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170312239-A1 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885KMT2A 4180/4885
US-10016381-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885KMT2A 4180/4885
US-20150265562-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885KMT2A 4180/4885
US-20150265563-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885KMT2A 4180/4885
US-20090048343-A1 Compounds and Their Salts Specific to the PPAR Receptors and the EGF Receptors and Their Use in the Medical Field EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885KMT2A 4180/4885
US-20150045436-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 GLO1 4010/4885FBP1 2098/4885KMT2A 4213/4885
US-20130005813-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885KMT2A 4180/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.