SCHEMBL1104866

SCHEMBL1104866

CO/C(=C\c1cccc([N+](=O)[O-])c1)C(=O)O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLO1 Q04760 2/20 0.61
FBP1 P09467 1/20 0.55
MAPT P10636 4/20 0.54
LMNA P02545 2/20 0.54
NFE2L2 Q16236 2/20 0.53
KMT2A Q03164 4/20 0.51
ALDH1A1 P00352 2/20 0.51
KDM4E B2RXH2 1/20 0.51
MEN1 O00255 3/20 0.51
MAPK1 P28482 1/20 0.50
MAOB P27338 1/20 0.50
TRPV1 Q8NER1 2/20 0.49
RAB9A P51151 2/20 0.49
NPC1 O15118 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
CYP1A2 P05177 2/20 0.48
CYP3A4 P08684 2/20 0.48
CYP2C19 P33261 1/20 0.48
TXNRD1 Q16881 1/20 0.48
TXNRD3 Q86VQ6 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1095397 1.00 GLO1 (0.61) GLO1FBP1MAPTLMNANFE2L2
SCHEMBL1095398 1.00 GLO1 (0.61) GLO1FBP1MAPTLMNANFE2L2
SCHEMBL1094959 0.89 GLO1 (0.61) GLO1FBP1MAPTLMNANFE2L2
SCHEMBL1094958 0.89 GLO1 (0.61) GLO1FBP1MAPTLMNANFE2L2
SCHEMBL1104890 0.89 GLO1 (0.61) GLO1FBP1MAPTLMNANFE2L2
SCHEMBL14477227 0.85 GLO1 (0.66) GLO1FBP1MAPTLMNANFE2L2
SCHEMBL1095264 0.85 GLO1 (0.66) GLO1FBP1MAPTLMNANFE2L2
SCHEMBL1095263 0.85 GLO1 (0.66) GLO1FBP1MAPTLMNANFE2L2
SCHEMBL7265045 0.82 GLO1 (0.73) GLO1FBP1MAPTLMNANFE2L2
SCHEMBL1094532 0.82 FBP1 (0.50) FBP1MAPTKMT2AALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10016381-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2018-07-10 US disclosed
US-20170312239-A1 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD GIULIANI INTERNATIONAL LIMITED (IE) 2017-11-02 US disclosed
US-20170312239-A1 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD GIULIANI INTERNATIONAL LIMITED (IE) 2017-11-02 US disclosed
US-9561202-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2017-02-07 US disclosed
US-9561202-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2017-02-07 US disclosed
US-9345680-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2016-05-24 US disclosed
US-9345680-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field NOGRA PHARMA LIMITED (IE) 2016-05-24 US disclosed
US-20150265562-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2015-09-24 US disclosed
US-20150265563-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2015-09-24 US disclosed
US-20150265563-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2015-09-24 US disclosed
US-20130005813-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field GIULIANI INTERNATIONAL LIMITED (IE) 2013-01-03 US disclosed
US-8153841-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field GIULIANI INTERNATIONAL LIMITED (IE) 2012-04-10 US disclosed
US-20090048343-A1 Compounds and Their Salts Specific to the PPAR Receptors and the EGF Receptors and Their Use in the Medical Field NOGRA PHARMA LIMITED (IE) 2009-02-19 US disclosed
WO-2007010516-A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD GIULIANI INTERNATIONAL LIMITED (IE) 2007-01-25 WO disclosed
US-4869913-A DIETETICS SCHERING AKTIENGESELLSCHAFT (DE) 1989-09-26 US disclosed
US-4769371-A VASODILATION E. R. SQUIBB & SONS, INC. (US) 1988-09-06 US disclosed
US-4522839-A 3-Substituted 2,4,6-trihalogenated benzamides as sweetening agents SCHERING AKTIENGESELLSCHAFT (DE) 1985-06-11 US disclosed
EP-0055689-B1 3-SUBSTITUTED 2,4,6-TRIHALOGENOBENZAMIDES AND THEIR SALTS, THEIR PREPARATION AND THEIR USE AS SUBSTITUTES FOR NATURAL SWEETENING AGENTS, AND SWEETENERS CONTAINING THEM SCHERING AKTIENGESELLSCHAFT (DE) 1984-07-04 EP disclosed
US-4429152-A DIABETES, DIETETICS SCHERING, AKTIENGESELLSCHAFT (DE) 1984-01-31 US disclosed
EP-0055689-A1 3-Substituted 2,4,6-trihalogenobenzamides and their salts, their preparation and their use as substitutes for natural sweetening agents, and sweeteners containing them SCHERING AKTIENGESELLSCHAFT (DE) 1982-07-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170312239-A1 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885MAPT 4794/4885
US-10016381-B2 Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885MAPT 4794/4885
US-20150265562-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885MAPT 4794/4885
US-20150265563-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885MAPT 4794/4885
US-20090048343-A1 Compounds and Their Salts Specific to the PPAR Receptors and the EGF Receptors and Their Use in the Medical Field EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885MAPT 4794/4885
US-20130005813-A1 Compounds and their Salts Specific to the PPAR Receptors and the EGF Receptors and their Use in the Medical Field EGFR, ERBB3, FGFR3 GLO1 4009/4885FBP1 1869/4885MAPT 4794/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.