Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10656284 | 0.89 | HPGD (0.50) | KMT2APOLBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL6373576 | 0.83 | CPS1 (0.49) | KMT2ASMN1; SMN2NPC1ALDH1A1HPGD | |
| SCHEMBL5990108 | 0.79 | NPC1 (0.53) | KMT2APOLBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL3308492 | 0.78 | KDM4E (0.58) | KMT2APOLBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL4935615 | 0.78 | NPC1 (0.60) | KMT2APOLBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL11049604 | 0.75 | MAPT (0.49) | KMT2APOLBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL11045406 | 0.75 | KMT2A (0.48) | KMT2APOLBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL10992317 | 0.75 | SMN1; SMN2 (0.45) | KMT2APOLBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL10660474 | 0.75 | KMT2A (0.61) | KMT2APOLBSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2591122 | 0.74 | HPGD (0.65) | KMT2ASMN1; SMN2NPC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487934-A | Method of preparing poly-substituted acylbenzenes | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1984-12-11 | — | — | US | disclosed |
| EP-0041682-B1 | A METHOD OF PREPARING POLY-SUBSTITUTED ACYLBENZENES | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-09-21 | — | — | EP | disclosed |
| EP-0045478-A1 | A method of preparing poly-substituted acylbenzenes | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-02-10 | — | — | EP | disclosed |
| EP-0041682-A1 | A method of preparing poly-substituted acylbenzenes | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-12-16 | — | — | EP | disclosed |
| US-4304941-A | Method of preparing poly-substituted acylbenzenes | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-12-08 | — | — | US | disclosed |