SCHEMBL11049849

SCHEMBL11049849

O=C(O)NCCC(c1ccc(C(F)(F)F)cc1)c1ccccn1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.48
EPHX2 P34913 3/20 0.48
LMNA P02545 2/20 0.44
ALDH1A1 P00352 1/20 0.44
CYP3A4 P08684 1/20 0.44
TSHR P16473 1/20 0.44
CYP2C19 P33261 1/20 0.44
KDM4E B2RXH2 1/20 0.44
RAB9A P51151 1/20 0.44
HRH3 Q9Y5N1 1/20 0.43
PMP22 Q01453 2/20 0.42
BLM P54132 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
TLR7 Q9NYK1 1/20 0.42
CHRM2 P08172 1/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
SCN1A P35498 1/20 0.42
SCN2A Q99250 1/20 0.42
SCN3A Q9NY46 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7294209 0.79 HRH3 (0.48) FFAR1LMNAALDH1A1TSHRHRH3
SCHEMBL14332939 0.77 KCNH2 (0.48) FFAR1ALDH1A1TLR7
Trifluoroacetic Acid SCHEMBL14334022 0.74 KCNH2 (0.47) FFAR1ALDH1A1TLR7
Trifluoroacetic Acid SCHEMBL14333509 0.72 FFAR1 (0.44) FFAR1ALDH1A1HRH3TLR7SLC6A2
SCHEMBL28709557 0.71 TLR7 (0.43) FFAR1KDM4EHRH3NPSR1TLR7
SCHEMBL28716573 0.71 TLR7 (0.43) FFAR1KDM4EHRH3NPSR1TLR7
SCHEMBL22445602 0.70 BLM (0.55) EPHX2LMNATSHRHRH3PMP22
SCHEMBL28842666 0.70 CHRM2 (0.50) LMNAALDH1A1CYP3A4TSHRCYP2C19
SCHEMBL28842668 0.70 CHRM2 (0.50) LMNAALDH1A1CYP3A4TSHRCYP2C19
SCHEMBL2726416 0.70 MTNR1A (0.72) EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4428948-A FUNGICIDES AGAINST PHYTOPATHOGENS ROHM AND HAAS COMPANY (US) 1984-01-31 US disclosed
US-4378357-A FUNGICIDES ROHM AND HAAS COMPANY (US) 1983-03-29 US disclosed