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SCHEMBL11050059

SCHEMBL11050059

C[C@H](N[C@@H](CCCCNS(=O)(=O)c1ccc(Cl)c(S(N)(=O)=O)c1)C(=O)O)C(=O)N1CCC[C@H]1C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ ACE P12821 8/20 0.52
▸ LMNA P02545 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11052803 0.92 ACE (0.56) ACELMNASMN1; SMN2
SCHEMBL11050251 0.92 ACE (0.56) ACELMNASMN1; SMN2
SCHEMBL11049931 0.87 ACE (0.51) ACE
SCHEMBL11026152 0.87 ACE (0.51) ACE
SCHEMBL11052834 0.85 ACE (0.46) ACELMNA
SCHEMBL7409739 0.83 ACE (0.47) ACELMNASMN1; SMN2
SCHEMBL7409731 0.83 ACE (0.47) ACELMNASMN1; SMN2
SCHEMBL11029537 0.80 ACE (0.55) ACELMNASMN1; SMN2
SCHEMBL7367043 0.78 ACE (0.62) ACELMNASMN1; SMN2
SCHEMBL9808269 0.78 ACE (0.62) ACELMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4431644-A CARDIOVASCULAR DISORDERS; DIURETICS SCHERING CORPORATION (US) 1984-02-14 — — US disclosed
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